Quality-by-Design for Bioprocess Optimization


CYBERnano has worked on different projects related to the optimization of quality and productivity in biomanufacturing processes. In each project, CYBERnano is implementing a data-driven modeling approach based on design of experiments and efficient data analysis tools. The same approach was also applied on the optimization of therapeutic schemes  to control the benefice-risk balance.

Exemple of results for the optimization of an extraction process. Trois facteur de production ont été testés: durée, température et ratio. Les courbes de niveau représentent une réponse liée à la quantité de produit récupéré.






















Example of results for the optimization of an anticancer treatment. Three therapeutic factors were tested and two response were analyzed.















[1] L. Tirand, T. Bastogne, D. Bechet, M. Linder, N. Thomas, C. Frochot, F. Guillemin, and M. Barberi- Heyob, “Response surface methodology: an extensive potential to optimize photodynamic therapy condi- tions in vivo,” International Journal of Radiation Oncology, Biology, Physics, vol. 75, no. 1, pp. 244–252, 2009.

[2] T. Bastogne, A. Richard, P. Sibille, and E. Bichon, “Optimized multivariable control of an industrial cement milling circuit,” in Proc. of the 3rd European Control Conference, vol. 4, (Roma, Italy), pp. 3098– 3104, September 1995.